Heme oxygenase-1-mediated host cell response inhibits the susceptibility of prostate cancer cells to retroviral infection and retards their proliferation

Authors

Zhao Hua Zhou, Food and Drug Administration
Namita Kumari, The Center For Sickle Cell Disease
Jennifer Catalano, FDA Center for Biologics Evaluation and Research
Sergei Nekhai, The Center For Sickle Cell Disease
Jasen Wise, SABiosciences-Qiagen
Kenneth M. Yamada, National Institute of Dental and Craniofacial Research (NIDCR)
Subhash Dhawan, FDA Center for Biologics Evaluation and Research

Document Type

Article

Publication Date

1-1-2013

Abstract

Xenotropic murine leukemia virus-related virus (XMRV) resembles endogenous murine leukemia virus and was used in this study as a model for a new retrovirus infecting human cells. We demonstrate that induction of an HO-1-mediated host cell response inhibited the susceptibility of LNCaP prostate cancer cells to XMRV infection and efficiently retarded the growth of these prostate cancer cells. Our studies delineate a role of HO-1 in the host defense against retroviral infections and may provide novel therapeutic strategies for the treatment of HO-1-sensitive prostate cancer.

Recommended Citation

Zhou, Zhao Hua; Kumari, Namita; Catalano, Jennifer; Nekhai, Sergei; Wise, Jasen; Yamada, Kenneth M.; and Dhawan, Subhash, "Heme oxygenase-1-mediated host cell response inhibits the susceptibility of prostate cancer cells to retroviral infection and retards their proliferation" (2013). The Center For Sickle Cell Disease Faculty Publications. 76.
https://dh.howard.edu/sicklecell_fac/76