Nephrotoxic effects of oxygen transport media in the isolated rat kidney

Authors

Richard M. Millis, The Center For Sickle Cell Disease
Joan D. Barber, The Center For Sickle Cell Disease
Winston A. Anderson, The Center For Sickle Cell Disease
Armand J. Gold, The Center For Sickle Cell Disease
Carlyle B. Storm, The Center For Sickle Cell Disease
Carl A. Reindorf, The Center For Sickle Cell Disease

Document Type

Article

Publication Date

1-1-1985

Abstract

Perfusion of isolated kidneys from rats demonstrated the following nephrotoxic effects of Fluosol-DA: decreased glomerular filtration rate (GFR), urine flow rate (UFR), and fractional reabsorption of potassium (FrK+) (P < 0.01). Fluosol-DA perfusions were at flow rates about equal to the physiologically normal rodent renal plasma flow rate of 4 ml/min. Stroma-free hemoglobin (SFH) perfusions, also at 4 ml/min, were associated with physiologically normal renal functions, as were those of control Krebs-Ringer bicarbonate (KRB) perfusions at 32 ml/min. © 1985, SAGE Publications. All rights reserved.

Recommended Citation

Millis, Richard M.; Barber, Joan D.; Anderson, Winston A.; Gold, Armand J.; Storm, Carlyle B.; and Reindorf, Carl A., "Nephrotoxic effects of oxygen transport media in the isolated rat kidney" (1985). The Center For Sickle Cell Disease Faculty Publications. 299.
https://dh.howard.edu/sicklecell_fac/299