Pitted red cell counts in sickle cell disease
Document Type
Article
Publication Date
1-1-1986
Abstract
Splenic reticuloendothelial function, as determined by pitted red cell counts in 114 pediatric patients with sickle cell disease, was evaluated. Patients with homozygous sickle cell disease (HbSS) had a mean pit count of 11.8 ± 7.0% and the count increased with age. Sickle cell hemoglobin C disease (HbSC) patients had a mean pit count of 4.9 ± 9.1%, the count being unaffected by age. One patient with HbS-(β° thalassemia had a count of 12%, while eight patients with HbS-β+thalassemia had a mean count of 0.4 ± 0.3%. There was one patient each with HbSS-α thalassemia, HbS-O Arab, and HbS-Lepore, and the pit counts were 4.9, 31.4, and 0.4%, respectively. In both HbSS and HbSC patients, the pit count was significantly lower in patients who had palpable spleens. The pit count may be used as a predictor of disease severity in the sickle cell disorders. © 1986 Raven Press, New York.
Recommended Citation
Fatunde, Oluyemisi J. and Scott, Roland B., "Pitted red cell counts in sickle cell disease" (1986). The Center For Sickle Cell Disease Faculty Publications. 285.
https://dh.howard.edu/sicklecell_fac/285
