Initial screening transferrin saturation values, serum ferritin concentrations, and HFE genotypes in Native Americans and whites in the Hemochromatosis and Iron Overload Screening Study

Authors

James C. Barton, The University of Alabama at Birmingham
R. T. Acton, The University of Alabama at Birmingham
L. Lovato, Wake Forest School of Medicine
M. R. Speechley, The University of Western Ontario
C. E. McLaren, University of California, Irvine
E. L. Harris, Kaiser Permanente Center for Health Research
D. M. Reboussin, Wake Forest School of Medicine
P. C. Adams, London Health Sciences Centre
F. W. Dawkins, The Center For Sickle Cell Disease
V. R. Gordeuk, The Center For Sickle Cell Disease
A. P. Walker, University of California, Irvine
Deborah Dixon, The University of Alabama at Birmingham
Susan Ferguson, The University of Alabama at Birmingham
Richard Jones, The University of Alabama at Birmingham
Jerry McKnight, The University of Alabama at Birmingham
Charles A. Rivers, The University of Alabama at Birmingham
Diane Tucker, The University of Alabama at Birmingham
Janice C. Ware, The University of Alabama at Birmingham
Gordon McLaren, University of California, Irvine
Hoda Anton-Culver, University of California, Irvine
Jo Ann A. Baca, University of California, Irvine
Thomas C. Bent, University of California, Irvine
Lance C. Brunner, University of California, Irvine
Michael M. Dao, University of California, Irvine
Korey S. Jorgensen, University of California, Irvine
Julie Kuniyoshi, University of California, Irvine
Huan D. Le, University of California, Irvine
Miles K. Masatsugu, University of California, Irvine
Frank L. Meyskens, University of California, Irvine
David Morohashi, University of California, Irvine
Huan P. Nguyen, University of California, Irvine
Sophocles N. Panagon, University of California, Irvine
Chi Phung, University of California, Irvine
Virgil Raymundo, University of California, Irvine

Document Type

Article

Publication Date

1-1-2006

Abstract

We compared initial screening transferrin saturation (TfSat) and serum ferritin (SF) phenotypes and HFE C282Y and H63D genotypes of 645 Native American and 43,453 white Hemochromatosis and Iron Overload Screening Study participants who did not report a previous diagnosis of hemochromatosis or iron overload. Elevated measurements were defined as TfSat >50% in men and >45% in women and SF>300 ng/ml in men and >200 ng/ml in women. Mean TfSat was 31% in Native American men and 32% in white men (p = 0.0337) and 25% in Native American women and 27% in white women (p < 0.0001). Mean SF was 153 mg/l in Native American and 151 μ/l in white men (p = 0.8256); mean SF was 55 μ/l in Native American women and 63 μ/l in white women (p = 0.0015). The C282Y allele frequency was 0.0340 in Native Americans and 0.0683 in whites (p < 0.0001). The H63D allele frequency was 0.1150 in Native Americans and 0.1532 in whites (p = 0.0001). We conclude that the screening TfSat and SF phenotypes of Native Americans are similar to those of whites. The allele frequencies of HFE C282Y and H63D are significantly lower in Native Americans than in whites. © Blackwell Munksgaard, 2006.

Recommended Citation

Barton, James C.; Acton, R. T.; Lovato, L.; Speechley, M. R.; McLaren, C. E.; Harris, E. L.; Reboussin, D. M.; Adams, P. C.; Dawkins, F. W.; Gordeuk, V. R.; Walker, A. P.; Dixon, Deborah; Ferguson, Susan; Jones, Richard; McKnight, Jerry; Rivers, Charles A.; Tucker, Diane; Ware, Janice C.; McLaren, Gordon; Anton-Culver, Hoda; Baca, Jo Ann A.; Bent, Thomas C.; Brunner, Lance C.; Dao, Michael M.; Jorgensen, Korey S.; Kuniyoshi, Julie; Le, Huan D.; Masatsugu, Miles K.; Meyskens, Frank L.; Morohashi, David; Nguyen, Huan P.; Panagon, Sophocles N.; Phung, Chi; and Raymundo, Virgil, "Initial screening transferrin saturation values, serum ferritin concentrations, and HFE genotypes in Native Americans and whites in the Hemochromatosis and Iron Overload Screening Study" (2006). The Center For Sickle Cell Disease Faculty Publications. 182.
https://dh.howard.edu/sicklecell_fac/182