Specimen Collection for Translational Studies in Hidradenitis Suppurativa

Authors

A. S. Byrd, Johns Hopkins School of Medicine
Y. Dina, Meharry Medical College
U. J. Okoh, Johns Hopkins School of Medicine
Q. Q. Quartey, University of Maryland School of Medicine
C. Carmona-Rivera, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
D. W. Williams, Johns Hopkins School of Medicine
M. L. Kerns, Johns Hopkins School of Medicine
R. J. Miller, Johns Hopkins School of Medicine
L. Petukhova, Columbia University
H. B. Naik, University of California, San Francisco
L. A. Barnes, Stanford University School of Medicine
W. D. Shipman, Memorial Sloan-Kettering Cancer Center
J. A. Caffrey, Johns Hopkins School of Medicine
J. M. Sacks, Johns Hopkins School of Medicine
S. M. Milner, Johns Hopkins School of Medicine
O. Aliu, Johns Hopkins School of Medicine
K. P. Broderick, Johns Hopkins School of Medicine
D. Kim, Johns Hopkins School of Medicine
H. Liu, Johns Hopkins School of Medicine
C. A. Dillen, Johns Hopkins School of Medicine
R. Ahn, University of California, Los Angeles
J. W. Frew, Liverpool Hospital
M. J. Kaplan, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
S. Kang, Johns Hopkins School of Medicine
L. A. Garza, Johns Hopkins School of Medicine
L. S. Miller, Johns Hopkins School of Medicine
A. Alavi, University of Toronto
M. A. Lowes, Rockefeller University
G. A. Okoye, Johns Hopkins School of Medicine

Document Type

Article

Publication Date

12-1-2019

Abstract

Hidradenitis suppurativa (HS) is a chronic inflammatory disorder characterized by painful nodules, sinus tracts, and scars occurring predominantly in intertriginous regions. The prevalence of HS is currently 0.053–4%, with a predominance in African-American women and has been linked to low socioeconomic status. The majority of the reported literature is retrospective, population based, epidemiologic studies. In this regard, there is a need to establish a repository of biospecimens, which represent appropriate gender and racial demographics amongst HS patients. These efforts will diminish knowledge gaps in understanding the disease pathophysiology. Hence, we sought to outline a step-by-step protocol detailing how we established our HS biobank to facilitate the formation of other HS tissue banks. Equipping researchers with carefully detailed processes for collection of HS specimens would accelerate the accumulation of well-organized human biological material. Over time, the scientific community will have access to a broad range of HS tissue biospecimens, ultimately leading to more rigorous basic and translational research. Moreover, an improved understanding of the pathophysiology is necessary for the discovery of novel therapies for this debilitating disease. We aim to provide high impact translational research methodology for cutaneous biology research and foster multidisciplinary collaboration and advancement of our understanding of cutaneous diseases.

Recommended Citation

Byrd, A. S.; Dina, Y.; Okoh, U. J.; Quartey, Q. Q.; Carmona-Rivera, C.; Williams, D. W.; Kerns, M. L.; Miller, R. J.; Petukhova, L.; Naik, H. B.; Barnes, L. A.; Shipman, W. D.; Caffrey, J. A.; Sacks, J. M.; Milner, S. M.; Aliu, O.; Broderick, K. P.; Kim, D.; Liu, H.; Dillen, C. A.; Ahn, R.; Frew, J. W.; Kaplan, M. J.; Kang, S.; Garza, L. A.; Miller, L. S.; Alavi, A.; Lowes, M. A.; and Okoye, G. A., "Specimen Collection for Translational Studies in Hidradenitis Suppurativa" (2019). College of Medicine Faculty Publications. 281.
https://dh.howard.edu/med_fac/281