Dietary iron intake and serum ferritin concentration in 213 patients homozygous for the HFEC282Y hemochromatosis mutation
BACKGROUND: HFEC282Y homozygotes have an increased risk for developing increased iron stores and related disorders. It is controversial whether dietary iron restrictions should be recommended to such individuals. OBJECTIVE: To determine whether dietary iron content influences iron stores in HFEC282Y homozygotes as assessed by serum ferritin concentration. DESIGN: Serum ferritin concentration was measured and a dietary iron questionnaire was completed as part of the evaluation of 213 HFE C282Yhomozygotes who were identified through screening of >100,000 primary care patients at five HEmochromatosis and IRon Overload Screening (HEIRS) Study Field Centers in the United States and Canada. RESULTS: No significant relationships between serum ferritin concentration and dietary heme iron content, dietary nonheme iron content or reports of supplemental iron use were found. CONCLUSION: These results do not support recommending dietary heme or nonheme iron restrictions for HFEC282Y homozygotes diagnosed through screening in North America. ©2012 Pulsus Group Inc. All rights reserved.
Gordeuk, Victor R.; Lovato, Laura; Barton, James C.; Vitolins, Mara; McLaren, Gordon; Acton, Ronald T.; McLaren, Christine; Harris, Emily L.; Speechley, Mark; Eckfeldt, John H.; Diaz, Sharmin; Sholinsky, Phyliss; and Adams, Paul, "Dietary iron intake and serum ferritin concentration in 213 patients homozygous for the HFEC282Y hemochromatosis mutation" (2012). The Center For Sickle Cell Disease Faculty Publications. 95.