Excess HLA antigens after transfusion of sickle cell patient with AIDS

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A woman with sickle cell‐hemoglobin C disease developed the acquired immunodeficiency syndrome (AIDS), possibly as the result of blood transfusions administered 4 years earlier. Three months after subsequent transfusions, she had excess HLA‐A and DR antigens (triplets) on her circulating lymphocytes. Three of her first‐degree relatives were HLA‐typed, and none had excess antigens. Family studies also indicated that the patient had at least one HLA‐A antigen that was probably not inherited. These findings suggest the possibility that transient hemopoietic engraftment can occur in transfused sickle cell patients with AIDS. Copyright © 1987 Wiley‐Liss, Inc., A Wiley Company

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