Title

Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations

Authors

Michelle Daya, University of Colorado Anschutz Medical Campus
Nicholas Rafaels, University of Colorado Anschutz Medical Campus
Tonya M. Brunetti, University of Colorado Anschutz Medical Campus
Sameer Chavan, University of Colorado Anschutz Medical Campus
Albert M. Levin, Henry Ford Health System
Aniket Shetty, University of Colorado Anschutz Medical Campus
Christopher R. Gignoux, University of Colorado Anschutz Medical Campus
Meher Preethi Boorgula, University of Colorado Anschutz Medical Campus
Genevieve Wojcik, Stanford University School of Medicine
Monica Campbell, University of Colorado Anschutz Medical Campus
Candelaria Vergara, Johns Hopkins University
Dara G. Torgerson, University of California, San Francisco
Victor E. Ortega, Wake Forest School of Medicine
Ayo Doumatey, National Institutes of Health (NIH)
Henry Richard Johnston, Emory University
Nathalie Acevedo, Universidad de Cartagena
Maria Ilma Araujo, Universidade Federal da Bahia
Pedro C. Avila, Northwestern University
Gillian Belbin, Icahn School of Medicine at Mount Sinai
Eugene Bleecker, University of Arizona College of Medicine – Tucson
Carlos Bustamante, Stanford University School of Medicine
Luis Caraballo, Universidad de Cartagena
Alvaro Cruz, Universidade Federal da Bahia
Georgia M. Dunston, Howard University College of Medicine
Celeste Eng, University of California, San Francisco
Mezbah U. Faruque, Howard University College of Medicine
Trevor S. Ferguson, Caribbean Institute for Health Research
Camila Figueiredo, Universidade Federal da Bahia
Jean G. Ford, Albert Einstein Healthcare Network
Weiniu Gan, National Heart, Lung, and Blood Institute (NHLBI)
Pierre Antoine Gourraud, Université de Nantes
Nadia N. Hansel, Johns Hopkins University
Ryan D. Hernandez, University of California, San Francisco
Edwin Francisco Herrera-Paz, Universidad Católica de Honduras

Document Type

Article

Publication Date

12-1-2019

Abstract

Asthma is a complex disease with striking disparities across racial and ethnic groups. Despite its relatively high burden, representation of individuals of African ancestry in asthma genome-wide association studies (GWAS) has been inadequate, and true associations in these underrepresented minority groups have been inconclusive. We report the results of a genome-wide meta-analysis from the Consortium on Asthma among African Ancestry Populations (CAAPA; 7009 asthma cases, 7645 controls). We find strong evidence for association at four previously reported asthma loci whose discovery was driven largely by non-African populations, including the chromosome 17q12–q21 locus and the chr12q13 region, a novel (and not previously replicated) asthma locus recently identified by the Trans-National Asthma Genetic Consortium (TAGC). An additional seven loci reported by TAGC show marginal evidence for association in CAAPA. We also identify two novel loci (8p23 and 8q24) that may be specific to asthma risk in African ancestry populations.

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