Genetic polymorphisms in IL-10 promoter are associated with smoking and prostate cancer risk in African Americans
Background/Aim: Even though prostate cancer (PCa) has good prognosis, there is a discrepancy in the risk among ethnic groups, with high morbidity in African American men. Single nucleotide polymorphisms (SNPs) in interleukin 10 (IL-10) have been associated with inflammation and cancer risk. We investigated the association of five SNPs in the IL-10 promoter with clinical features such as Gleason score and smoking. Materials and Methods: A total of 413 DNA samples were obtained from a nested case-control study of African American males who were genotyped for 5 SNPs utilizing pyrosequencing. Multiple and binary logistic regression models were applied to analyze the clinical and genotypic data. Results: rs12122923 and rs1800871 were associated with PCa risk. Smoking was also found to increase the risk of PCa by 1.6-fold. rs1800893 was found to be associated with lower grades for prostate cancer. Conclusion: IL-10 promoter polymorphisms might be a risk factor for PCa development in smoking subjects and PCa progression.
Abbas, Muneer; Mason, Tshela; Ibad, Aliza; Khraiwesh, Mozna; Apprey, Victor; Kanaan, Yasmine; Wilson, Bradford; Dunston, Georgia; Ricks-Santi, Luisel; and Brim, Hassan, "Genetic polymorphisms in IL-10 promoter are associated with smoking and prostate cancer risk in African Americans" (2020). College of Medicine Faculty Publications. 263.