A Pediatric Case of Transformed Mycosis Fungoides in a BRCA2 Positive Patient

Authors

Andrea M. Gross, Childrens National Health System
Joyce Turner, Childrens National Health System
Anna Y. Kirkorian, Childrens National Health System
Ginette A. Okoye, Howard University College of Medicine
Dragos C. Luca, Childrens National Health System
Miriam Bornhorst, Childrens National Health System
Shana S. Jacobs, Childrens National Health System
Kirsten M. Williams, Childrens National Health System
Reuven J. Schore, Childrens National Health System

Document Type

Article

Publication Date

7-1-2020

Abstract

Cutaneous T-cell lymphomas are very rare in children. Although mycosis fungoides is the most common of these rare cutaneous T-cell lymphomas in children, transformation to an aggressive malignancy remains extremely uncommon, and there are no clear guidelines for clinical management in the pediatric population. In addition, the increased usage of next-generation sequencing for pediatric patients with unusual malignancies may result in the discovery of pathogenic germline mutations, though the association between these mutations and the patient's cancer is not always clear. We present here a unique pediatric case of transformed mycosis fungoides in a patient with BRCA2 mutation.

Recommended Citation

Gross, Andrea M.; Turner, Joyce; Kirkorian, Anna Y.; Okoye, Ginette A.; Luca, Dragos C.; Bornhorst, Miriam; Jacobs, Shana S.; Williams, Kirsten M.; and Schore, Reuven J., "A Pediatric Case of Transformed Mycosis Fungoides in a BRCA2 Positive Patient" (2020). College of Medicine Faculty Publications. 212.
https://dh.howard.edu/med_fac/212