Comparative Effects of Fluorides on Mice Femurs

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Groups of mice were given the fluoride compounds-NaF, Na2SiFe, CaF2, and KF-in 1:100,000 dilutions ad libitum via their drinking water for 45 days. In addition, other mice received distilled water. The femurs of animals so treated were compared histologically with each other and with those from the tap water control animals. It was noted that there was a similarity of some, but not all, of the results obtained with NaP and NaSiF6. Also noted, with the exception of NaF and Na2SiF,, was a dissimilarity of results obtained with the other fluoride compounds. Alterations taking place are described with reference to the components of the growth center; the epiphyseal plates, the cartilagenous plates, the trabeculae, and the blood vessels. It was observed that the cartilagenous plates, trabeculae, and terminal plates were heaviest where CaF2 had been administered. Terminal plates were thinner, cartilage plates were also thinner, but had numbers of cells lined up in columns, and trabeculae were ragged where NaF and Na2SiF6 was given. Where KF had been given, there was a very sharp border between the terminal plates and cartilage, trabeculae were fewer in number, and the epiphyseal cartilage was thin with small, disorderly, atropic cell formations. Where distilled water had been given, cartilage was irregular and had variations in maturity, trabeculae were thinner, but terminal plates were thicker and more diverse than with tap water controls. Blood vessels were markedly increased with CaF2, and they were less numerous than with NaP, NaSiF6, and KP. © 1959, Sage Publications. All rights reserved.

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