Pulpal and periapical tissue response to butyl 2-cyanoacrylate

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A series of experiments was conducted with the use of butyl 2-cyanoacrylate and cavity varnish on traumatically exposed pulps in the albino rat. Histologic comparisons were made between three groups of animals, showing that the sealing effect of the cavity varnish was dissipated in between 1 and 7 days. Cyanoacrylate produced immediate hemostasis and a delay in the inflammatory response. Granuloma and cyst formation occurred in the nontreated animals at 21 and 49 days, respectively, but a similar effect was not seen in the cyanoacrylate-treated specimen until the ninety-first day. Marked giant-cell reaction was observed in the nontreated and cavity-varnish-treated animals as early as 7 days but was not seen in the cyanoacrylate-treated group before 91 days; nor was there a change in the appearance of the periodontal ligament space or the inter-radicular bone of the latter group until the ninety-first day. Inflammatory response was seen in the nontreated group as early as the first day. Enlargement of the pulpal blood vessels was seen in the cyanoacrylate-treated animals and, although a disturbance of the orderly palisade arrangement of the odontoblasts was noted, these cells remained viable at the end of 70 days and did not completely loose their viability until the ninety-first day. These experiments show that butyl 2-cyanoacrylate may have an ameliorative effect upon exposed pulpal tissue in the albino rat for 90 days. © 1969.

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